100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Show More
Indications of Frenvas 20
Primary hypercholesterolemia is a condition in which there is an abnormally high level (heterozygous familial and nonfamilial), Dyslipidemia with a mix of lipids, Homozygous familial hypercholesterolemia, Hypertriglyceridemia, Familial hypercholesterolemia, Preventing cardiovascular events, Primary dysbetalipoproteinemia
Pharmacology of Frenvas 20
Atorvastatin is a selective HMG-CoA reductase inhibitor. This enzyme is responsible for the rate-limiting conversion of HMG-CoA to mevalonate, a precursor of sterols including cholesterol. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver, as well as increasing the number of hepatic LDL receptors on the cell surface, allowing for improved LDL uptake and catabolism.
Dosage & Administration
Adults with primary hypercholesterolemia and mixed hyperlipidemia:
Usually, 10 mg once a day; if necessary, may be raised at least every 4 weeks to a maximum of 80 mg once daily.
Child (10-18 years): Start with 10 mg once daily, then gradually raise to the normal maximum of 20 mg once a day at least 4-week intervals.
Adults with familial hypercholesterolemia:
Start with 10 mg daily and gradually increase to 40 mg once daily over at least 4 weeks; if required, increase to a maximum of 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).
Child (10-18 years): Start with 10 mg once a day and gradually raise to the normal maximum of 80 mg once daily at least 4-week intervals.
Adults: Start with 10 mg once a day and gradually increase based on response.
Interaction of Frenvas 20
May increase risk of myopathy and rhabdomyolysis w/ CYP3A4 potent inhibitor (e.g. HIV or HCV protease inhibitors, itraconazole, clarithromycin), fenofibrate, colchicines, fixed combination of lopinavir/ritonavir. With a CYP3A4 inducer, plasma concentrations may be reduced (e.g. rifampicin, efavirenz). Digoxin AUC and peak plasma concentrations may be significantly increased. AUC for norethindrone and Ethinyl estradiol has increased.
Contraindications
Hypersensitivity, active liver disease or unexplained persistent serum transaminase elevations, porphyria, pregnancy, and lactation
Side Effects of Frenvas 20
In most cases, atorvastatin is well tolerated. Constipation, flatulence, dyspepsia, and stomach discomfort are the most common adverse effects of Atorvastatin. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other adverse effects.
Pregnancy & Lactation
During pregnancy, atorvastatin is not recommended. Pregnant women's safety has not been demonstrated. There have been no controlled clinical studies using atorvastatin in pregnant women. There have been a few instances of congenital abnormalities following intrauterine exposure to HMG-CoA reductase inhibitors. Animal investigations have revealed that it is harmful to reproduction. Maternal atorvastatin therapy may lower fetal levels of mevalonate, a precursor of cholesterol production. Atorvastatin should not be taken in pregnant women, women who are attempting to get pregnant, or women who believe they are pregnant. Treatment with atorvastatin should be discontinued for the length of the pregnancy or until the woman is proven to be not pregnant.
The presence of atorvastatin or its metabolites in human milk is unknown. The plasma concentrations of atorvastatin and its active metabolites in rats are comparable to those found in milk. Women taking atorvastatin should not breastfeed their children due to the risk of significant adverse effects. Taking atorvastatin during nursing is not advised.
Precautions & Warnings
Patients who drink a large amount of alcohol. A family history of liver disease. Patients who are at risk for myopathy or rhabdomyolysis. Prior to beginning statin treatment, hypothyroidism should be well controlled. Children under the age of ten Females in their premenstrual period. Lactation: Because of the risk of adverse effects in nursing infants, women taking this medication should not breastfeed; nursing moms should avoid taking it.
Storage Conditions
Keep away from light and heat in a dry area. Keep out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.